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James C. A. Bardwell

James Bardwell wants to understand – and optimize – how proteins fold within the cell. To do so, Bardwell’s team uses directed evolution via a variety of biochemical, biophysical, and genetic...

SCIENTISTS

Catherine L. Drennan

Catherine Drennan studies enzymes that contain metals or metallo-cofactors, to understand how nature uses them to catalyze challenging chemical reactions. She’s also interested in metalloproteins...

SCIENTISTS

Catherine Drennan

Cathy Drennan is interested in determining the structures of metalloproteins. As a professor, she trains graduate students and postdocs to be teacher-scholars and lectures in large freshman...

SCIENTISTS

Robert J. Lefkowitz

Robert Lefkowitz is interested in the molecular and regulatory properties of G protein-coupled receptors (GPCRs). Lefkowitz and his team focus on understanding how cell signaling is mediated...

SCIENTISTS

Michael K. Rosen

Michael Rosen wants to understand how cells stay organized. His work focuses on enigmatic compartments within a cell, called biomolecular condensates, which concentrate proteins and nucleic acids...

ALUMNI

Edward M. De Robertis

Investigator: 1994-2019

NEWS Dec 11 2009

Making Stronger Proteins that Can Tackle Tougher Jobs

Proteins—the building blocks of life—are sensitive beasts. Heat them a few degrees, or otherwise stress them, and they tend to fall apart. Now, Howard Hughes Medical Institute investigator James...

NEWS Sep 8 2014

Peter Walter Receives Albert Lasker Basic Medical Research Award

The Albert and Mary Lasker Foundation announced today that Howard Hughes Medical Institute (HHMI) investigator Peter Walter of the University of California, San Francisco (UCSF) and Kazutoshi Mori of...

NEWS May 21 2007

Researchers Create Molecule-Sized Test Tubes

In a Howard Hughes Medical Institute laboratory in Illinois, a new kind of “test tube,” one-thousandth the diameter of a human hair and small enough to hold only a few molecules of DNA, is...

NEWS Jan 15 2015

Luke Lavis to Deliver Next Public Talk at Janelia

Janelia group leader Luke Lavis will deliver the next lecture in the Dialogues of Discovery series at Janelia Research Campus in Ashburn, Virginia. Lavis’ talk, “The Chemistry of Color...

NEWS Sep 18 2009

Right-handed Amino Acids Help Bacteria Adapt

The insides of cells are swimming with amino acids, essential chemical building blocks of life. But flip one of these molecules around, so that it is a mirror image of its former self, and the cell...

NEWS Nov 18 2007

Twitching Proteins Caught in the Act

New research has shown that some enzymes fidget constantly, even as they wait to catalyze a reaction. The study, from Howard Hughes Medical Institute investigator Dorothee Kern, shows that enzymes...

NEWS Feb 10 2006

Immune Cells May Pave the Way for Prostate Cancer

A new research study suggests that the very cells that target invading pathogens and mop up dead cells may also permit prostate cancer to flourish under certain conditions. In an article published in...

NEWS Nov 27 2005

Biotechnology's Newest Chemical Tool

Exploiting biology's own chemical toolbox, researchers have developed a new technique that will allow them to modify specific sequences within a DNA molecule. The approach will not only help reveal...

BULLETIN ARTICLE Nov 1 2011

Intellectual Ferment

Chemistry was the focus of my academic interests when I arrived as a freshman on the campus of the University of California, Berkeley. But unlike countless undergraduates everywhere, it wasn’t...

BULLETIN ARTICLE Sep 1 2013

The Guide on the Side

Students in Harold “Hal” White’s sophomore biochemistry course don’t lounge in their seats, taking notes while he lectures from the front of the classroom. They cluster in small groups,...

BULLETIN ARTICLE May 1 2010

Biomolecular Crowdsourcing

A generation of Web-savvy entrepreneurs has found a relatively cheap and effective approach to solving complex problems and soliciting ideas: toss out a challenge into a vibrant digital community...

SCIENCE EDUCATION TOPICS

Expert Q&A: Mike Summers

BULLETIN ARTICLE Nov 1 2010

Plant Science Matters

Vicki Chandler’s research on how plants regulate their genes may ultimately inform studies of human diseases. She’s leading the Gordon and Betty Moore Foundation’s partnership with HHMI to...

LEADERSHIP

Bodo Stern

As chief of strategic initiatives, Stern works directly with HHMI’s president and senior executive team to formulate and execute the organization’s strategic initiatives and direction, with...

BULLETIN ARTICLE Sep 1 2012

What part of your job would people find the most surprising?

...

NEWS Apr 20 2012

Two HHMI Scientists Elected to the Royal Society

Howard Hughes Medical Institute (HHMI) investigator Bonnie L. Bassler of Princeton University and Jack E. Dixon, vice president and chief scientific officer at HHMI, have been elected as foreign...

NEWS Feb 12 2009

Krystal R. St. Julien

Krystal R. St. Julien’s own hemoglobin got her hooked on biochemistry. Born with sickle cell anemia—a painful genetic disorder that causes red blood cells to become rigid and clump together when they...

NEWS Oct 17 2006

UTSW Medical Center Symposium to Honor David L. Garbers

The University of Texas Southwestern Medical Center at Dallas is honoring the life and legacy of the late David L. Garbers by hosting a memorial symposium on November 16, 2006. Garbers, a...

LEADERSHIP

Janet Shaw

As a Scientific Officer, Janet Shaw serves as a liaison to HHMI Investigators at universities and research centers in the U.S. regarding scientific and administrative matters. She attends all HHMI...

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James C. A. Bardwell

Catherine L. Drennan

Catherine Drennan

Robert J. Lefkowitz

Michael K. Rosen

Edward M. De Robertis

Making Stronger Proteins that Can Tackle Tougher Jobs

Peter Walter Receives Albert Lasker Basic Medical Research Award

Researchers Create Molecule-Sized Test Tubes

Luke Lavis to Deliver Next Public Talk at Janelia

Right-handed Amino Acids Help Bacteria Adapt

Twitching Proteins Caught in the Act

Immune Cells May Pave the Way for Prostate Cancer

Biotechnology's Newest Chemical Tool

Intellectual Ferment

The Guide on the Side

Biomolecular Crowdsourcing

Expert Q&A: Mike Summers

Plant Science Matters

Bodo Stern

What part of your job would people find the most surprising?

Two HHMI Scientists Elected to the Royal Society

Krystal R. St. Julien

UTSW Medical Center Symposium to Honor David L. Garbers

Janet Shaw

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James C. A. Bardwell

Catherine L. Drennan

Catherine Drennan

Robert J. Lefkowitz

Michael K. Rosen

Edward M. De Robertis

Making Stronger Proteins that Can Tackle Tougher Jobs

Peter Walter Receives Albert Lasker Basic Medical Research Award

Researchers Create Molecule-Sized Test Tubes

Luke Lavis to Deliver Next Public Talk at Janelia

Right-handed Amino Acids Help Bacteria Adapt

Twitching Proteins Caught in the Act

Immune Cells May Pave the Way for Prostate Cancer

Biotechnology's Newest Chemical Tool

Intellectual Ferment

The Guide on the Side

Biomolecular Crowdsourcing

Expert Q&A: Mike Summers

Plant Science Matters

Bodo Stern

What part of your job would people find the most surprising?

Two HHMI Scientists Elected to the Royal Society

Krystal R. St. Julien

UTSW Medical Center Symposium to Honor David L. Garbers

Janet Shaw

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