Youxing Jiang’s research is aimed at understanding the structure and function of a class of membrane proteins called ion channels. Specifically, Jiang and his team seek to understand the mechanisms of ion selectivity and gating properties among tetrameric cation channels. The team is currently focused on organellar cation channels, such as those localized to the lysosome and mitochondria. They are employing protein crystallography and single-particle cryo-electron microscopy to determine the channel's 3-D structures, and electrophysiology to elucidate the functional properties among these proteins. Jiang’s research will facilitate understanding of ion channel regulation of basic biological processes and contribute to studies of channel-related human diseases.