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Yi Zhang seeks to understand how epigenetic-mediated changes in chromatin structure affect gene expression, which in turn regulates mammalian development and disease. Working in cultured cells and mice, Zhang and his team have applied biochemical and functional approaches to identify and characterize numerous chromatin-modifying enzymes over the past decade. More recently, Zhang’s team has broadened its research interests to include epigenetic mechanisms in embryonic development, stem cell reprogramming, animal cloning, drug addiction, and cancer and is using techniques such as single-cell live imaging, single-cell RNA-seq, merFISH, optogenetics, and CRISPR/Cas9-based genomic and epigenomic editing, among others.