Enzymes catalyze some of the most challenging chemical reactions—such as nitrogen fixation and methane oxidation—under mild conditions. However, their vast synthetic potential remains largely untapped. Yang Yang integrates chemistry, biology, and artificial intelligence to design and evolve novel enzyme functions that transcend the boundaries of natural biology and traditional chemistry. His lab aims to uncover the fundamental biochemical, biophysical, and design principles that govern enzymatic function, enabling the rapid and precise synthesis of therapeutic agents—from complex small molecules to biomacromolecules—to drive innovation in biomedical science.