How do genes and molecules orchestrate the formation of the brain—and how do these processes go awry? Xin Jin’s lab develops scalable, in vivo functional genomics technologies to decode how genetic programs shape brain circuits across development, homeostasis, and disease. By integrating in vivo CRISPR screening with molecular, spatial, and whole-brain imaging approaches, her team dissects how genetics influence distinct cell types and tissue architectures. Through these innovations, the lab aims to uncover the fundamental principles by which genomes build and maintain complex neural systems over time.