Valentina Greco and her team take a visual approach to understand how cells behave in the skin of live mice. They view cell behaviors as an expression of the architecture of the tissue in which the cells are embedded, much like human behaviors are an expression of the structures in which we are embedded. The lab seeks to understand the mechanisms that direct the cooperation of cells within a tissue to sustain function over a lifetime. How do stem cells balance regenerative behaviors, such as division and differentiation, across scales? Why is skin cancer relatively rare even though mutations are frequent in the skin? How is the natural balance of collective cell behaviors preserved in the skin across a lifetime?