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Thomas Südhof is interested in how synapses form in the brain, how their properties are specified, and how they accomplish the rapid and precise signaling essential to information processing. To study the molecular basis of neural circuits and synaptic information transfer, Südhof and his team use an interdisciplinary approach ranging from structural biology and mouse genetics to electrophysiology and mouse behavior. Their overall aim is to contribute to the understanding of disorders in which synaptic transmission is impaired, including Alzheimer’s disease, schizophrenia, and autism.