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Sue Biggins wants to understand the mechanisms that regulate cell division and chromosome segregation to ensure accurate self-renewal, proliferation, and development. Biggins and her team focus particularly on the kinetochore, the protein structure that assembles onto chromatin and attaches to the spindle to physically pull chromosomes into daughter cells. Working in yeast and human cells, the team takes a comprehensive approach to understanding the assembly, functions, and architecture of the kinetochore and the underlying specialized centromeric chromatin.