Current Research
Retrovirus Replication and Associated Protein Interactions

Stephen Goff wants to understand the replication of retroviruses and the interactions between viral and host proteins that occur during that process. Goff and his team primarily study two retroviruses: the Moloney murine leukemia virus and the human immunodeficiency virus type 1 (HIV-1). A major focus of their work is the loading of histones on retroviral DNA and the silencing of viral expression. The team is also characterizing a retroviral element associated with a clonally contagious leukemia-like disease in the mollusk Mya arenaria, the soft-shell clam. The team employs a variety of approaches in their investigations, including molecular genetics, biochemistry, the two-hybrid system, and genetic screens in mammalian cell culture.

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