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Stephen Bell researches the assembly of replisomes – multi-enzyme cellular structures that work to replicate chromosomes – and how they are properly regulated during cell division. Bell’s team seeks to recapitulate these events in the test tube and uses high resolution techniques, such as single-molecule fluorescence, to elucidate how the many proteins involved in chromosome replication work together to unwind and duplicate the DNA that forms the foundation of each chromosome. His work aims to shed light on this critical process, which, when dysfunctional, can lead to cell death, developmental abnormalities, or cancer.