Current Research
Organization and Dynamics of Macromolecular Assemblies

Stephen Harrison studies the atomic structures of macromolecular assemblies, including viruses and protein-and-nucleic acid complexes, to understand how they function in cells. Through x-ray crystallography, cryo-EM, and related biochemical and biophysical approaches, Harrison and his team seek to produce “molecular movies” that show how macromolecules assemble. The team is documenting how the human immune response to influenza drives and responds to viral evolution, and how kinetochores direct faithful chromosome segregation. Their goal is to decipher how viruses infect healthy cells and to identify how macromolecular machinery contributes to cellular function.

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