Each of our cells contains nearly two meters of DNA that needs to be compacted and organized to fit within the confines of the cell. This organization impacts which genes are active, influencing cell function and fate. Disruptions in this process can lead to cancer, intellectual disability, and developmental delay. Seychelle Vos aims to understand the connection between genome organization and gene expression. She studies RNA polymerase II, the molecular machine which transcribes most protein coding genes, and its interactions with genome organization at various levels. Her research will help uncover how cells achieve specific functions.