Robert Lamb is interested in the replication of influenza virus and paramyxoviruses. Specifically, Lamb and his team investigate the molecular structure and replication mechanisms of influenza A, B, and C viruses and the paramyxovirus PIV5. These pathogens and their relatives are responsible for numerous biologically and economically consequential diseases of humans and other animals. They serve as excellent models for studying a variety of integral membrane proteins, particularly those that allow viruses to enter cells and assemble at the plasma membrane. A better understanding of these processes may aid in the development of vaccines and other therapeutics.