Current Research
RNA-binding Proteins in the Mammalian Brain

Robert Darnell wants to understand the proteins that regulate RNA and thereby affect gene expression. Darnell and his team are particularly interested in neuron-specific RNA-binding proteins in the mammalian brain, and in functional genomics and human disease more generally. The team uses a combination of biochemical and genetic approaches – including high-throughput genomics – in their studies, and recently developed a powerful method (CLIP) to create genome-wide maps of RNA-binding interaction sites in living tissue. Their findings have provided functional insight into RNA dysregulation in diseases such as autism, hepatitis, and Alzheimer’s.

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