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Richard Locksley wants to understand the cellular and molecular underpinnings of allergic immunity. Working in mice, Locksley and his team study the interactions between innate and adaptive immune cells during allergic inflammation and use these insights to guide their understanding of the role of these cells in normal tissue physiology. Such studies have uncovered unexpected roles for immune cells in metabolism and tissue integrity, and have clarified functions for rare epithelial tuft cells in these responses. The team’s overall aim is to understand the evolutionary pressures underlying populations of innate immune cells that when dysregulated manifest as widespread allergic diseases such as asthma and food allergies.