Current Research
Molecular and Cellular Basis of the Immune Response
Richard Flavell wants to understand the cellular and molecular mechanisms responsible for the body’s immune response. Flavell and his team use transgenic and gene-targeted mice to study innate and adaptive immunity, T cell tolerance and activation in immunity and autoimmunity, apoptosis, and regulation of T cell differentiation. The team currently focuses their work on three major areas: T cell differentiation and its contribution to immune homeostasis, the biology of inflammasomes and intestinal microbiota, and humanized mouse models for the study of immunity.