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Randy Schekman is interested in membrane assembly, vesicular transport, and membrane fusion among organelles of the secretory pathway. Schekman and his team apply basic principles they developed from studies of a simple eukaryote, yeast, to investigate the mechanisms of intracellular vesicular transport and biogenesis of extracellular vesicles (exosomes) in cultured human cells. Their current work is devoted to understanding how proteins and RNA are sorted into extracellular vesicles and how these molecules may be delivered to target cells in relation to normal and pathological functions.