Current Research
The Unfolded Protein Response and Beyond

Peter Walter is focused on finding molecular answers to fundamental questions in cell biology. To that end, his lab studies how cells control the quality of their proteins and organelles during homeostasis, and in response to internal and external stresses.

Over the years, Walter’s lab group has identified cellular machinery and mechanisms that ensure proper protein synthesis, folding, and targeting. They have also uncovered pathways that allow organelles to communicate and regulate their abundance, such as the unfolded protein response – a quality control system that adjusts the endoplasmic reticulum’s capacity according to need. Historically, much of the lab’s work started in yeast and established key principles that the group then extended to mammalian systems.

The Walter lab’s current focus is on understanding how rewiring of basic and phylogenetically conserved processes of protein quality control can lead to, or prevent, the progression of disease. In this quest, the group uses a diverse array of approaches – ranging from biophysics and biochemistry to classical and chemical genetics – to fuel the search for fundamental discoveries and their application to disease models.

Grants from the National Institutes of Health and industry provided partial support for these projects.

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