Researchers have designed a molecule that sticks tightly to the coronavirus spike protein, preventing the virus from infecting cells. The molecule might someday be used in an aerosolized drug to treat or prevent COVID-19. Activity goes awry for hundreds of genes in Down syndrome, the most common genetic cause of intellectual disability. Scientists have now found a way to calm the disordered activity – and restore cognitive abilities in mice. A drug that reverses the effects of a cellular stress response restores learning and memory in mice with concussions. Now researchers can see the atomic-scale details of how the drug interacts with its protein target. HHMI Investigators Joanne Chory and Peter Walter are among five scientists honored for transformative advances toward understanding living systems and extending human life. HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University. Peter Walter shares prize for discovery of the unfolded protein response of the endoplasmic reticulum. HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.