Current Research
Communication Between Cells and Organs in Drosophila
Norbert Perrimon wants to understand how cells, tissues, and organs communicate during development. Working in Drosophila, Perrimon’s lab group uses techniques such as genome-wide RNAi and CRISPR screening and large-scale mass spectrometry to identify components of signaling networks and points of intersection, or “cross-talk nodes,” between signaling pathways that produce coherent responses. A more thorough understanding of these events can help elucidate how different tissues and cell types integrate within an organ, and how complex phenotypes arise in animals.