Current Research
Visualizing Biomolecules and Their Assemblies with Cryo-EM

Nikolaus Grigorieff wants to visualize cellular macromolecular assemblies in atomic detail, to better understand the mechanisms underlying their function. To do this, Grigorieff and his team develop methods in cryo-electron microscopy (cryo-EM) that use a “single-particle” approach, eliminating the need for crystallization. Recently, the team and collaborators have begun developing a method to detect molecules and assemblies in situ – inside cells – for a more complete spatial understanding of local distributions and to preserve weak and transient interactions otherwise missed. Grigorieff makes the tools developed in his lab available to other scientists, including open-source software to process cryo-EM data.

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