Current Research
Cell Growth and Proliferation in Cancer

Nikola Pavletich is interested in the structural biology of pathways that are altered in cancer. Mutations and other alterations in these pathways lead to the uncoupling of cell growth from regulatory signals and contribute to the unrestricted proliferation of the tumor cell. Pavletich and his team use X-ray crystallography and other methods to map the three-dimensional shape of the molecular components that control cell growth and understand them at a mechanistic level. The team focuses particularly on the structures and mechanisms of proteins that sense, signal, and repair DNA damage, and on the mTOR growth regulatory pathway.

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