Current Research
Mechanism and Regulation of Homologous Recombination

Neil Hunter studies homologous recombination, an essential DNA-repair process required for genome stability and accurate chromosome segregation during meiotic cell division. Working in budding yeast and mice, Hunter and his team use specialized techniques and “real-time genetics” to dissect the molecular machinery underlying recombination and to pinpoint how it is regulated. Because meiotic recombination is highly conserved across species, the team’s discoveries are relevant for understanding the process in humans, for whom errors in meiosis can lead to pregnancy miscarriage and congenital disease.

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