Michele Pagano studies how the large family of human ubiquitin ligase enzymes, essential factors in the degradation of regulatory proteins, controls cell proliferation. Pagano and his team often use discovery-driven data analyses, leading them to explore new areas of research. As a result, they have expanded their work – initially focused on cell-cycle control – to encompass multiple aspects of cellular signaling and cancer biology. The team’s current goal is to reveal key regulatory mechanisms underlying fundamental biological responses and behaviors for which dysregulation results in cancer. Pagano’s long-term goal is to develop new anticancer therapies based on novel concepts of protein degradation.