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Michael Rosbash is interested in the RNA processing, genes, and mechanisms that underlie circadian rhythms – the 24-hour pacemaker that is nearly ubiquitous among higher organisms. Using Drosophila as a model system, Rosbash and his team study the mechanisms and importance of neuronal circuitry and plasticity to circadian rhythms, as well as the contributions of transcriptional and posttranscriptional regulation. They also study how circadian clocks function within the brain to influence sleep and the enigmatic process of temperature compensation.