Current Research
DNA Replication, Recombination, and Repair

Michael O’Donnell is interested in the replication mechanisms of DNA. O’Donnell and his team study these replication mechanisms to understand how certain proteins work together to make copies of DNA, and how they function with repair and recombination factors to ensure accuracy of those copies. Currently the team is focused on eukaryotic replisome function, how it deals with histones, and how that relates to epigenetic inheritance. They are applying tools such as single-molecule technologies and single-particle reconstruction by electron microscopy to understand how the replisome functions with other factors.

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