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Massimo Scanziani focuses on the mechanisms underlying the neuronal circuits that control spatial and temporal activity in the mammalian brain cortex. Working in rodents, Scanziani and his team use electrophysiological, imaging, optogenetic, and anatomical techniques as well as behavioral approaches. The work spans from in vitro analysis of biophysical properties of single neurons to in vivo recordings from neuronal populations during sensory stimulation in awake, behaving animals. Their goal is to understand the role of each individual element of a neuronal circuit in sensory processing, thus bridging the gap between system and cellular neuroscience.