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Mark Davis is interested in understanding how the immune system’s T and B lymphocytes recognize specific antigens, and in addressing the unique challenges of studying the human immune system. Working in mice, Davis and his team use advanced imaging techniques to identify the key molecular events in the T cell recognition process. The team applies biochemical and systems biology approaches in their studies of the human immune system, to gain a better understanding of the role of different immune system components in vaccine responses and disease, and to assess the role of genetics versus the environment.