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Mariana Byndloss wants to understand how disruption of beneficial host-microbiota metabolic interactions contributes to human disease. Focusing on the interactions between gut microbes and intestinal epithelial cells, she is investigating the effects of intestinal epithelial dysfunction in the pathogenesis of infections and noncommunicable diseases. By pursuing how the intestinal epithelium responds to microbiota imbalance caused by diet, antibiotics, or infection with enteric pathogens, Byndloss hopes to create novel therapeutic strategies focusing on the intestinal epithelium and the gut microbiota as potential targets for treating infectious gastroenteritis and noncommunicable diseases such as obesity, inflammatory bowel disease, and colorectal cancer.