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Although the nervous system and the immune system are often considered distinct biological domains, emerging evidence suggests that these systems interact extensively in the contexts of both health and disease. Lucas Cheadle merges in vivo multi-photon imaging with single-cell genomics to define the roles of immune cells in shaping brain development, plasticity, and function. In parallel, Cheadle investigates the inflammatory signals that disrupt neural circuit maturation in disorders of brain development, such as autism. Cheadle’s ultimate goal is to design new therapeutic strategies for treating neurodevelopmental disorders through the pharmacological manipulation of neuro-immune interactions.