Current Research
Developmental Biology of Hematopoiesis and Cancer

Leonard Zon wants to understand the biology of vertebrate blood development, or hematopoiesis, and what happens when it goes awry. Zon and his team dissect hematopoietic development in zebrafish, a model organism whose blood-forming system, and some blood disorders, share similarities with those of humans. Using chemical and genetic screens as well as analysis of novel transgenic zebrafish lines, Zon’s team investigates questions related to stem cell biology, the genetics of bone marrow transplantation, and different aspects of cancers, such as the epigenetics of onset and mechanisms of drug resistance in melanoma.

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