Krystyna Keleman seeks to uncover the mechanistic basis of memory formation and persistence by studying in Drosophila a naturally occurring form of memory called courtship memory. Specifically, Keleman and her team aim to determine circuit and molecular mechanisms of how distinct forms of memory are formed and how their persistence is determined. Over the past several years, they exploited the advantages of the Drosophila model system and uncovered molecular and circuit basis contributing to short and long-term memory formation. More recently, the team made inroads in the understanding how sleep benefits memory retention. Currently, their main research focus is elucidating the mechanisms underlying sleep dependent long-term memory consolidation.