Current Research
Structural Biology of Genome Organization

Karolin Luger wants to understand the impact of chromatin architecture on genome-related processes such as gene transcription, DNA replication, and DNA repair. Luger and her team apply structural biology and biophysics tools as well as imaging, genomic, and genetic approaches to determine how chromatin is assembled and disassembled during these processes. The team also investigates the ancient origins of eukaryotic chromatin through studies of archaeal chromatin and chromatin-associated factors. Luger’s work may have significance for diseases involving proteins associated with DNA repair, such as cancer.

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