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Karl Deisseroth is focused on developing and applying high-resolution tools for controlling and mapping specific well-defined elements within intact biological systems. Deisseroth and his team develop and then use these and other tools – integrated with optical, electrophysiological, computational, molecular, and behavioral approaches – to study neural physiology and behavior in freely moving mammals. Their ultimate aim is to understand the neural circuit dynamics underlying normal behavior as well as the pathological neural circuit dynamics underlying neuropsychiatric disease.