Current Research
Molecular and Genetic Basis of Circadian Rhythms

Joseph Takahashi wants to understand circadian rhythms in mammals. Circadian rhythms are key to maintaining homeostasis and their disruption has been associated with neurological and metabolic changes in humans and other mammals, such as sleeping sickness, bipolar disorder, and aging. Takahashi and his team use the mouse as a model organism to discover genes associated with the regulation of circadian behaviors and the team applies techniques from genomics, biochemistry and structural biology to investigate the genes’ functions in the molecular mechanisms underlying the circadian clock.

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