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Jonathan Weissman is interested in how cells ensure that proteins fold into their correct shapes. Weissman and his team focus on identifying and understanding the machinery necessary for efficient folding, as well as studying the mechanism and consequences of protein misfolding. They also develop experimental and analytical approaches for exploring the organizational principles of complex cellular systems and for monitoring protein translation in vivo with unprecedented precision and depth. The ability to bridge large-scale approaches and mechanistic investigations is a key focus of the lab.