Current Research
Signaling Proteins: Mechanism, Evolution, and Structure

John Kuriyan wants to understand the mechanisms, evolution, and structures of the molecular switches responsible for cellular signal transduction. Using approaches in biochemistry, biophysics, and structural and cell biology, Kuryian and his team strive to elucidate mechanisms, and to study how these mechanisms change with evolution. A major focus is to understand the exquisite sensitivity of protein switches to signaling perturbations, in order to determine the molecular principles governing regulation and specificity. The work is providing insight into how misregulation of these proteins contributes to cancer and immune diseases.

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