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Johannes Walter’s research focuses on how vertebrate cells achieve high-fidelity replication of their genomes. Using single-molecule imaging and a powerful cell-free system developed in his lab, Walter and his team study the molecular machines that replicate DNA and how they overcome damage and other obstacles in the DNA template strands. The team also seeks to understand the roles of tumor suppressor pathways in promoting DNA repair. Their findings help illuminate the causes of genomic instability in hereditary cancers and may inform cancer therapies.