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Jiefu Li investigates the operating principles of cell-surface signaling in the nervous and immune systems and crosstalk between them. Cell-surface signaling mediates intercellular adhesion and communication, thus it controls nearly every aspect of the development and physiology of both systems. To obtain systemic and mechanistic insights into these operating principles, Li and his team innovate new tools and methods for quantitative proteomics and advanced imaging and analyze cell-surface signaling at systems, cellular, and molecular levels.