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Jay Shendure is interested in developing and applying new technologies and methods for genetics, genomics, and molecular biology. Most of the work of Shendure and his team broadly exploits next-generation DNA sequencing as an effective way to measure biological phenomena. Their current projects fall generally into six areas: developing new molecular methods; genomic approaches to developmental biology; massively parallel functional genomics; translating genomics to the clinic; the genetic basis of human disease; and genome sequencing technologies. Ultimately, Shendure’s aim is to develop innovations that make a big impact on our understanding of biology and disease.