HomeOur ScientistsJ. Paul Taylor

Our Scientists

J. Paul Taylor, MD, PhD
Investigator / 2015–Present
J. Paul Taylor

Scientific Discipline

Molecular Biology, Neuroscience

Host Institution

St. Jude Children's Research Hospital

Current Position

Dr. Taylor is also the Edward F. Barry Endowed Chair of Cell and Molecular Biology at St. Jude Children’s Research Hospital.

Research

Nervous System Function in Development and Disease

Paul Taylor trained as a clinical neurologist. He now spends his days in a research lab investigating how the nervous system develops and functions, but his studies always begin with what he learns from patients.

Beginning with genes that are disrupted in patients with neurodegenerative diseases, Taylor's lab team first determines the normal function of those genes and then looks at how their mutation causes disease, taking advantage of any model or experimental system that gets the researchers closer to an answer.

This strategy has led Taylor to discover that some neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia, are caused by defects in the assembly, disassembly, or clearance of cellular packages of RNA and protein known as RNA granules. He has shown that these types of defects in RNA metabolism can also cause degenerative muscle diseases.

Taylor's team is now investigating the role of RNA granules in regulating gene activity and exploring how the granules are assembled.

Education

  • MD, PhD, Jefferson Medical College, Philadelphia
  • Neurology Residency, University of Pennsylvania
  • Neurogenetics Fellowship, National Institute of Neurological Disorders and Stroke

Awards

  • Derek Denny-Brown Neurological Scholar Award, American Neurological Association

Memberships

  • Association of American Physicians
  • American Society for Clinical Investigation
  • American Neurological Association