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Isabel Espinosa Medina studies how the nervous system and the cells of organs, specifically the pancreas, interact during development and in disease states. The autonomic nervous system connects the different organs of the body with the brain to regulate homeostasis, but very little is known about how the early brain-organ axis is established and maintained. Espinosa Medina and her team use state-of-the-art imaging and genetic tools for temporal manipulation of cells in zebrafish and mice to define the cellular origins and interactions underlying the development of the neuroendocrine system, which regulates lifelong glucose homeostasis.