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Huda Zoghbi wants to understand the mechanisms underlying brain development and degeneration. Working primarily in mouse models and humans, Zoghbi and her team study the activities of proteins involved in neuropsychiatric disorders such as Rett syndrome, MECP2 duplication syndrome, and mania. They also collaborate with labs studying Drosophila to study the function of proteins that accumulate in late-onset degenerative diseases like Alzheimer’s and inherited movement disorders such as Spinocerebellar ataxia type 1 (SCA1).  The team’s goal is to find ways to reduce abnormal accumulation of proteins in degenerative conditions and normalize protein levels in developmental diseases.