Current Research
Function and Regulation of Protein-Modifying Enzymes

Hening Lin is interested in enzymes that post-translationally modify proteins, including nicotinamide adenine dinucleotide (NAD)-consuming enzymes, such as sirtuins and ADP-ribosyltransferases, and the ZDHHC family of palmitoyltransferases. Lin and his team combine organic chemistry, biochemistry, cell biology, and mouse genetics to discover new enzymatic activities and understand the physiological function of these enzymes. They specifically emphasize work on the regulation of the enzymes because such regulation often reveals key physiological functions, enabling the team to develop small molecule inhibitors as potential therapeutics for treating human diseases.

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