Current Research
Vascular Wall Development, Homeostasis, and Disease

Harry (Hal) Dietz is focused on the study and care of patients with heritable vascular connective tissue disorders that predispose to vascular dissection and/or rupture, including Marfan syndrome, Loeys-Dietz syndrome, vascular Ehlers-Danlos syndrome, and Sphrintzen-Goldberg syndrome. Dietz and his team have shown that the multisystem pathogenesis of each of these disorders relates to crosstalk between the transforming growth factor b (TGFb), angiotensin II (AngII), and mitogen-activated protein kinase pathways. Their research integrates clinical care, disease gene identification, mechanistic studies in animal models, natural history studies, and treatment trials. Clinical work focuses on the diagnosis and chronic management of heritable connective tissue disorders in individuals from birth to late old age.

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