Hal Dietz is interested in the etiology and pathogenesis of inherited forms of vascular disease. Dietz and his team focus primarily on the homeostasis of the arterial wall, with interest in syndromic presentations of thoracic aortic aneurysm. The team is also focused on understanding the mechanisms and vulnerabilities for fibrosis, a fundamental disease process thought to contribute to up to forty percent of deaths worldwide. Experimental approaches include disease gene identification using human genetic techniques, animal modeling, genetic modifier studies and genetic or pharmacologic provocations to elucidate mechanism. These studies are aimed at identification of novel therapeutic strategies.