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Harald Hess is interested in developing high-throughput 3D electron microscopy and super-resolution 3D optical microscopy for use in brain connectomics and cell biology. Hess and his team work closely with researchers at Janelia and elsewhere to devise systems that transcend the challenges associated with imaging living biological systems. By taking a coherent systems approach to such challenges, the team aims to bridge diverse fields, nucleate and drive collaborations, and be driven by new research opportunities identified by scientists worldwide.