Current Research
Ribonucleoprotein Complexes and Transcriptome Regulation

Gideon Dreyfuss is interested in the role of RNA-binding proteins (RNPs) and their complexes with RNA in regulating gene expression, and how their dysfunction plays a role in disease. Dreyfuss and his team are primarily focused on the SMN complex, an RNP assembly machine that, when deficient, leads to the motor neuron degenerative disease known as spinal muscular atrophy (SMA). In addition, they are studying the mechanisms underlying splicing regulation and developing high-throughput technologies for research and drug discovery applicable to SMA and other diseases.

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