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Evgeny Nudler is interested in the molecular mechanisms of cellular adaptation to stress. Working in both prokaryotic and eukaryotic species, Nudler and his team investigate how cells rapidly detect damage to their macromolecules (DNA and proteins) to promptly activate corrective processes. A cell’s failure to react appropriately has major pathological and evolutionary consequences, such as mutagenesis, cellular transformation, aging, and cell death. The team uses various model systems, including bacteria, nematodes, and mammalian cells to study these processes, and have developed powerful genomic, proteomic, and analytical tools to enhance their research capabilities.