Erik Jorgensen is interested in the molecular basis of synaptic transmission. Working in C. elegans and the mouse, Jorgensen and his team focus on four main areas: neurotransmitters, exocytosis, endocytosis, and genome engineering. They seek to understand neuroendocrine secretion in response to environmental changes, such as the presence of food or mates. In addition, they study the neuronal circuits that generate rhythmic behavior. Recent work includes demonstration of an ultrafast mechanism of endocytosis at C. elegans and mouse hippocampal synapses.