Cancer is a single-cell evolutionary process fueled by mutations and large chromosomal aberrations. Every tumor consists of a unique combination of altered features affecting thousands of genes. The wide range of chromosome numbers found across tumors is astounding, ranging from fewer than 46 to more than 92, and this genomic diversity makes it difficult to predict characteristics like growth, metastasis, and response to treatment. Emma Watson is interested in how tumor genome structure and composition relate to function. The Watson lab utilizes high-throughput genomic technologies to explore the vast phenotypic spaces generated by tumor genomic shuffling and chromosomal imbalance.