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Elaine Fuchs studies adult stem cells that reside in the skin – where they come from and how they make and repair tissues. Fuchs and her team explore how stem cells communicate with neighboring cells, including immune cells, and how this changes in response to wounding and pathogens.  Working with mice, the team employs classical genetics, RNAi, CRISPR-Cas and high throughput genomic technologies to unravel the pathways that balance stem cell maintenance and differentiation in normal tissue and in wound-repair, and to investigate aberrant routes in aging, inflammation and cancers. Their work is advancing our understanding of tissue regeneration, wound healing and inflammatory disorders as well as malignancy and tumor resistance.